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Infectious and noninfectious functions of cGAS
Structure of the complex of chicken STING and human TBK1.
The role of ubiquitination in the RIG-I antiviral signaling pathway
Ubiquitin-mediated activation of TAK1 and IKK in IL-1R/TLR pathways
Welcome to Dr. Zhijian "James" Chen’s Lab at the UT Southwestern Medical Center.
We are broadly interested in mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself. In particular, we are fascinated by how a cell detects harmful or foreign insults and mounts an appropriate response to restore homeostasis.
Please explore our website to learn more about our people and our research.
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