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Infectious and noninfectious functions of cGAS.jpg

Infectious and noninfectious functions of cGAS

STING TBK1.webp

Structure of the complex of chicken STING and human TBK1.

The role of ubiquitination in the RIG-I antiviral signaling pathway .jpeg

The role of ubiquitination in the RIG-I antiviral signaling pathway

Ubiquitin-mediated activation of TAK1 and IKK in IL-1RTLR pathways .jpeg

Ubiquitin-mediated activation of TAK1 and IKK in IL-1R/TLR pathways

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Welcome to Dr. Zhijian "James" Chen’s Lab at the UT Southwestern Medical Center.

We are broadly interested in mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself. In particular, we are fascinated by how a cell detects harmful or foreign insults and mounts an appropriate response to restore homeostasis.

Please explore our website to learn more about our people and our research.

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CONTACT US

5323 Harry Hines Blvd, Dallas, TX 75390

Phone: 214-648-1145

FAX: 214-648-1675

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