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Infectious and noninfectious functions of cGAS.jpg

Key roles of cGAS in health and disease

STING TBK1.webp

Structure of STING-TBK1 complex

The role of ubiquitination in the RIG-I antiviral signaling pathway .jpeg

The RIG-I - MAVS antiviral signaling pathway

Ubiquitin-mediated activation of TAK1 and IKK in IL-1RTLR pathways .jpeg

Ubiquitin-mediated activation of TAK1 and IKK in IL-1R/TLR pathways

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Welcome to Dr. Zhijian "James" Chen’s Lab at the UT Southwestern Medical Center.

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We are broadly interested in mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself. In particular, we are fascinated by how a cell detects harmful or foreign insults and mounts an appropriate response to restore homeostasis.

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Please explore our website to learn more about our people and our research.

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CONTACT US

5323 Harry Hines Blvd, Dallas, TX 75390

zhijian.chen@utsouthwestern.edu

Phone: 214-648-1145

FAX: 214-648-1675

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