PUBLICATIONS

References and Links to Papers

PRIMARY RESEARCH PAPERS

Jenson, J. M., Li, T., Du, F., Ea, C.-K., & Chen, Z. J. (2023). Ubiquitin-like Conjugation by Bacterial cGAS Enhances Anti-phage Defence. Nature. doi:10.1038/s41586-023-05862-7

Wu, Y. T., Fang, Y., Wei, Q., Shi, H., Tan, H., Deng, Y., Zeng, Z., Qiu, J., Chen, C., Sun, L., & Chen, Z. J. (2022). Tumor-targeted delivery of a STING agonist improvescancer immunotherapy. Proceedings of the National Academy of Sciences of the United States of America, 119(49), e2214278119. https://doi.org/10.1073/pnas.2214278119

Fang, Y., Sun, P., Xie, X., Du, M., Du, F., Ye, J., Kalveram, B. K., Plante, J. A., Plante, K. S., Li, B., Bai, X.-c., Shi, P.-Y. & Chen, Z. J. (2022) An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif. Science Immunology 0, eabp9962, doi:doi:10.1126/sciimmunol.abp9962.

Du, M., Ea, C. K., Fang, Y., & Chen, Z. J. (2022). Liquid phase separation of NEMO induced by polyubiquitin chains activates NF-κB. Molecular cell, S1097-2765(22)00293-3. Advance online publication. https://doi.org/10.1016/j.molcel.2022.03.037

Li, T., Yum, S., Li, M., Chen, X., Zuo, X., & Chen, Z. J. (2022). TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance. The Journal of experimental medicine, 219(1), e20211539.

Hu, S., Fang, Y., Chen, X., Cheng, T., Zhao, M., Du, M., Li, T., Li, M., Zeng, Z., Wei, Y., Gu, Z., Zhang, C., Sun, L., & Chen, Z. J. (2021). cGAS restricts colon cancer development by protecting intestinal barrier integrity. Proceedings of the National Academy of Sciences of the United States of America, 118(23), e2105747118.

Yum, S., Li, M., Fang, Y., and Chen, Z.J. (2021). TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections. Proceedings of the National Academy of Sciences 118, e2100225118.

Li, T., Huang, T., Du, M., Chen, X., Du, F., Ren, J., and Chen, Z.J. (2021). Phosphorylation and chromatin tethering prevent cGAS activation during mitosis. Science 371, eabc5386.

Gui, X., Yang, H., Li, T., Tan, X., Shi, P., Li, M., Du, F., and Chen, Z.J. (2019). Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature 567, 262-266.

Shang, G., Zhang, C., Chen, Z.J., Bai, X.-c., and Zhang, X. (2019). Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP. Nature 567, 389-393.

Zhang, C., Shang, G., Gui, X., Zhang, X., Bai, X.-c., and Chen, Z.J. (2019). Structural basis of STING binding with and phosphorylation by TBK1. Nature 567, 394-398.

Chen, J., and Chen, Z.J. (2018). PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature 564, 71-76.

Du, M., and Chen, Z.J. (2018). DNA-induced liquid phase condensation of cGAS activates innate immune signaling. Science 361, 704-709.

Yang, H., Wang, H., Ren, J., Chen, Q., and Chen, Z.J. (2017). cGAS is essential for cellular senescence. Proceedings of the National Academy of Sciences 114, E4612-E4620.

Luo, M., Wang, H., Wang, Z., Cai, H., Lu, Z., Li, Y., Du, M., Huang, G., Wang, C., Chen, X., et al. (2017). A STING-activating nanovaccine for cancer immunotherapy. Nature Nanotechnology 12, 648-654.

Wang, H., Hu, S., Chen, X., Shi, H., Chen, C., Sun, L., and Chen, Z.J. (2017). cGAS is essential for the antitumor effect of immune checkpoint blockade. Proceedings of the National Academy of Sciences 114, 1637-1642.

Chen, Q., Sun, L., and Chen, Z.J. (2016). Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing. Nature Immunology 17, 1142-1149.

Collins, Angela C., Cai, H., Li, T., Franco, Luis H., Li, X.-D., Nair, Vidhya R., Scharn, Caitlyn R., Stamm, Chelsea E., Levine, B., Chen, Zhijian J., et al. (2015). Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis. Cell Host & Microbe 17, 820-828.

Gao, D., Li, T., Li, X-D., Chen, X., Li, Q-Z., Wight-Carter, M., and Chen, Z.J. (2015) Activation of Cyclic GMP-AMP Synthase by Self DNA Causes Autoimmune Diseases. Proc Natl Acad Sci U S A. 112, E5699-705.

Collins, A.C., Cai, H., Li, T., Franco, L.H., Li, X-D., Nair, V.R., Scharn, C.R., Stamm, C.E., Levine, B., Chen, Z.J*., Shiloh, M.U*. (2015) Cyclic GMP-AMP synthase is an innate immune sensor of Mycobacterium tuberculosis DNA. Cell Host Microbe 17, 820-828. *co-corresponding author

Liu, S., Cai, X., Wu, J., Cong, Q., Chen, X., Li, T., Du, F., Ren, J., Wu, Y., Grishin, N., and Chen, Z.J. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING and TRIF induces IRF3 activation. Science 347, aaa2630.

Ren, J., Chen, X., and Chen, Z.J. (2014) IKKbeta Is An IRF5 Kinase that Instigates Inflammation. Proc Natl Acad Sci USA 111, 17438–17443.

Cai, X., Chen, J., Xu, H., Liu, S., Jiang, Q.X., Halfmann, R., and Chen, Z.J. (2014) Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation. Cell. 156(6):1207-22.

Xu, H., He, X., Zheng, H., Huang, L.J., Hou, F., Yu, Z., de la Cruz, M.J., Borkowski, B., Zhang, X., Chen, Z.J., and Jiang, Q.X. (2014) Structural basis for the prion-like MAVS filaments in antiviral innate immunity. Elife. 3:e01489.

Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C.A., Zhang, X., and Chen, Z.J. (2014) The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Rep. 6(3):421-30.

Li, X.D., Wu, J., Gao, D., Wang, H., Sun, L., and Chen, Z.J. (2013) Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects. Science 341(6152):1390-4.

Liu, S., Chen, J., Cai, X., Wu, J., Chen, X., Wu, Y-T., Sun, L., and Chen, Z.J. (2013) MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. eLife 2:e00785.

Gao, D., Wu, J., Wu, Y-T., Du, F., Aroh, C., Yan, N., Sun, L., and Chen, Z.J. (2013) Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses. Science 341:903-906.

Zhang, X., Shi, H., Wu, J., Zhang, X., Sun, L., Chen, C., and Chen, Z.J. (2013) Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol. Cell 51:226-235.

Sun, L., Wu, J., Du, F., Chen, X., and Chen, Z.J. (2012) Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway. Science 339, 786-791.

Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C., and Chen Z.J. (2012) Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA. Science 339, 826-830.

Li, X.D., and Chen, Z.J. (2012) Sequence specific detection of bacterial 23S ribosomal RNA by TLR13. Elife 1, e00102.

Jiang, X., Kinch, L., Brautigam, C.A., Chen, X., Du, F., Grishin, N., and Chen, Z.J. (2012) Ubiquitin-induced oligomerization of RIG-I and MDA5 activates antiviral innate immune response. Immunity 36, 959-973.

Tanaka, Y., and Chen, Z.J. (2012). STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway. Science Signaling 5, ra20.

Skaug, B., Chen, J., Du, F., He, J, Ma, A., and Chen, Z.J. (2011) Direct, non-catalytic mechanism of IKK inhibition by A20. Molecular Cell 44, 559-571.

Hou, F., Sun, L., Zheng, H., Skaug, B., Jiang, Q.X., and Chen, Z.J. (2011). MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response. Cell 146, 448-461.

Li, X.D., Chiu, Y.H., Ismail, A.S., Behrendt, C.L., Wight-Carter, M., Hooper, L.V., and Chen, Z.J. (2011). Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis. Proc Natl Acad Sci USA 108, 17390-17395.

Zeng, W., Sun, L., Jiang, X., Chen, X., Hou, F., Adhikari, A., Xu, M., and Chen, Z.J. (2010) Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity. Cell 141, 315-330.

Zhao, M., Li, X.D., and Chen, Z. J. (2010) CC2D1A, a DM14 and C2 domain protein, activates NF-kappaB through the canonical pathway. J Biol Chem 285, 24372-24380.

Zeng, W., Xu, M., Liu, S., Sun, L., Chen, Z.J. (2009) Key role of Ubc5 and K63 polyubiquitination in viral activation of IRF3. Molecular Cell 36, 302-314.

Xu, M., Skaug, B., Zeng, W., and Chen, Z.J. (2009) A ubiquitin replacement strategy reveals distinct mechanisms of IKK activation by TNFa and IL-1b. Molecular Cell 36, 315-325.

Xia, Z.P., Sun, L., Chen, X., Pineda, G., Jiang, X., Adhikari, A., Zeng, W., and Chen, Z.J. (2009). Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 461, 114-119.

Chiu, Y.H., Macmillan, J.B., and Chen, Z.J. (2009). RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138, 576-591.

Bhoj, V.G., Sun, Q., Bhoj, E., Somers, C., Chen, X., Torres, J-P., Mejias, A., Gomez., A., Jafri, H., Ramilo, O., Chen, Z.J. (2008). MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc. Natl. Acad. Sci. USA 105, 14046-14051.

Chiu, Y-H., Sun, Q., and Chen, Z.J. (2007) E1-L2 activates both ubiquitin and FAT-10. Molecular Cell 27, 1014-1023.

Sun, Q., Sun, L., Liu, H-H., Chen, X., Seth, R.B., Forman, J. and Chen, Z.J. (2006) The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24, 633-642.

Ea, C-K., Deng, L., Xia, Z-P., Pineda, G., and Chen, Z.J. (2006) Activation of IKK by TNFa requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Molecular Cell 22, 245-257.

Liu, H-H., Xie, M., Schneider, M.D., and Chen, Z.J. (2006) The essential role of TAK1 in thymocyte development and activation. Proc. Natl. Acad. Sci. USA 103, 11677-11682.

Li, X-D., Sun, L., Seth, R.B., Pineda, G., and Chen, Z.J. (2005) The Hepatitis C Virus Protease NS3/4A Cleaves MAVS off the Mitochondria to Evade Innate Immunity. Proc. Natl. Acad. Sci. USA 102, 17717-17722.

Seth, R.B., Sun, L., Ea, C., and Chen, Z.J. (2005) Identification and characterization of MAVS: a mitochondrial antiviral signaling protein that activates NF-kB and IRF3. Cell 122, 669-682.

Kanayama, A., Seth, R.B., Ea, C-K, Hong, M., Shaito, A., Deng, L., and Chen, Z.J. (2004) TAB2 and TAB3 activate the NF-kB pathway through binding to polyubiquitin chains. Molecular Cell 15, 535-548.

Sun, L., Deng, L., Ea, C-K., Xia, Z-P., and Chen, Z.J. (2004) The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Molecular Cell 14, 289-301.

Ea, C-K., Sun, L., Inoue, J-I, and Chen, Z.J. (2004) TIFA activates IKK by promoting the oligomerization and ubiquitin ligase activity of TRAF6. Proc. Natl. Acad. Sci. 101, 15318-15323.

Wang, C., Deng, L., Hong, M. Akkaraju, G.R., Inoue, J-i., and Chen, Z.J. (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351.

Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., and Chen, Z.J. (2000) Activation of the IkB kinase complex requires a dimeric ubiquitin conjugating enzyme complex and the formation of a unique polyubiquitin chain. Cell 103, 351-361.

Spencer, E., Jiang, J., and Chen, Z.J. (1999) Signal-induced ubiquitination of IkBa by the F-box protein, Slimb/b-TrCP. Genes & Dev. 13, 284-294.

REVIEWS AND PREVIEWS

Ablasser, A., and Chen, Z.J. (2019). cGAS in action: Expanding roles in immunity and inflammation. Science 363, eaat8657.

Li, T., and Chen, Z.J. (2018). The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer. Journal of Experimental Medicine 215, 1287-1299.

Cai, X., Xu, H., and Chen, Z.J. (2017). Prion-Like Polymerization in Immunity and Inflammation. Cold Spring Harb Perspect Biol 9.

Tan, X., Sun, L., Chen, J., and Chen, Z.J. (2015). Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids. Annual Review of Microbiology 72, 447-478.

Cai, X., Xu, H., and Chen, Z.J. (2016) Prion-like polymerization in immunity and cell death. Cold Spring Harb Perspect Biol. pii: a023580. doi: 10.1101/cshperspect.a023580

Chen, Q., Sun, L., and Chen, Z.J. (2016) Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing. Nat Immunol. 17. 1142-1149

Cai, X., and Chen, Z.J. (2014) Prion-like polymerization as a signaling mechanism. Trends Immunol 35, 622-630.

Cai, X., Chiu, Y.H., and Chen, Z.J. (2014) The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling. Mol Cell 54, 289-296.

Wu, J., and Chen, Z.J. (2014) Innate immune sensing and signaling of cytosolic nucleic acids. Annual Review of Immunology 32, 461-488.

Chen, J, Chen, Z.J. (2013) Regulation of NF-κB by ubiquitination. Curr Opin Immunol 25(1):4-12.

Chen, Z.J., and Ye, J. (2012) Getting to grips with hepatitis. elife 1, e00301.

Chen, Z.J. (2012). Ubiquitination in signaling to and activation of IKK. Immunol Rev 246, 95-106.

Yan, N., and Chen, Z.J. (2012). Intrinsic antiviral immunity. Nat Immunol 13, 214-222.

Jiang, X., and Chen, Z.J. (2012). The role of ubiquitylation in immune defence and pathogen evasion. Nat Rev Immunol 12, 35-48.

Jiang, Q.X., and Chen, Z.J. (2011). Structural insights into the activation of RIG-I, a nanosensor for viral RNAs. EMBO Rep 13, 7-8.

Jiang, X., and Chen, Z.J. (2011). Viperin links lipid bodies to immune defense. Immunity 34, 285-287.

Liu, S., and Chen, Z.J. (2011). Expanding role of ubiquitination in NF-kappaB signaling. Cell Res 21, 6-21.

Sun, L., Liu, S., and Chen, Z.J. (2010) SnapShot: Pathways of Antiviral innate immunity. Cell 140, 436.

Skaug, B., and Chen, Z.J. (2010) Emerging role of ISG15 in antiviral immunity. Cell 143, 187-190.

Bhoj, V.G., and Chen, Z. J. (2009) Ubiquitylation in innate and adaptive immunity. Nature 458, 430-437.

Skaug B., Jiang, X., and Chen,Z. J. (2009) The role of ubiquitin in NF-kB Regulatory Pathways. Annu. Rev. Biochem. 78, 769-796.

Adhikari, A., and Chen, Z.J. (2009) Diversity of polyubiquitin chains. Developmental Cell 16, 485-486.

Chen, Z.J., and Sun, L.J. (2009). Nonproteolytic functions of ubiquitin in cell signaling. Molecular Cell 33, 275-286.

Chiu, Y.H., Zhao, M., and Chen, Z.J. (2009) Ubiquitin in NF-kB Signaling. Chemical Review 109, 1549-1560.

Zeng, W., and Chen, Z.J. (2008) MITAgating viral infection. Immunity 29, 513-515.

Bhoj, V.G., and Chen, Z. J. (2008) Linking retroelements to autoimmunity. Cell 134, 569-571.

Bhoj, V.G., and Chen, Z. J. (2008) Mitochondrial antiviral signaling. In Cellular Signaling and Innate Immune Responses to RNA Virus Infections. A. Brasier, A. Garcia-Sastre, S.M. Lemon, eds. (Washington D.C: ASM Press). pp 39-51.

Seth, R. B., and Chen, Z. J. (2007). Smads keep TABs on inflammation. Nat Immunol 8, 477-478.

Adhikari, A., Xu, M., and Chen, Z. J. (2007). Ubiquitin-mediated activation of TAK1 and IKK. Oncogene 26, 3214-3226.

Fitzgerald K.A., and Chen, Z.J. (2006) Sorting out Toll signals. Cell 125, 834-836.

Seth, R. B., Sun, L., and Chen, Z. J. (2006). Antiviral innate immunity pathways. Cell Res 16, 141-147.

Chen, Z. J., Bhoj, V., and Seth, R. B. (2006). Ubiquitin, TAK1 and IKK: is there a connection? Cell Death Differ. 1-6.

Schulman, B. A., and Chen, Z. J. (2005). Protein ubiquitination: CHIPping away the symmetry. Molecular Cell 20, 653-655.

Chen, Z.J. (2005) Ubiquitin signaling in the NF-kB pathway. Nature Cell Biology 7, 758-765.

van Oers, N. S., and Chen, Z. J. (2005). Kinasing and clipping down the NF-kB trail. Science 308, 65-66.

Xia, Z. P., and Chen, Z. J. (2005). TRAF2: a double-edged sword? Sci STKE 2005, pe7.

Pineda, G., Ea, C-K., and Chen, Z.J. (2005) Ubiquitination and TRAF signaling. In TRAFs. H, Wu, eds. Landes Bioscience.

Sun, L., and Chen, Z.J. (2004). The novel functions of ubiquitination in signaling. Curr Opin Cell Biol 16, 119-126.

Chen, Z.J. and Fuchs, S. Y. (2004). Ubiquitin-dependent activation of NF-kB: K63-linked ubiquitin chains – a link to cancer? Cancer Biol Ther 3, 286-288.

Deng, L., and Chen, Z.J. (2003) Role of ubiquitin in NF-kB signaling. In Nuclear Factor kB. Regulation and Role in Disease. R. Beyaert, eds. (Kluwer). pp 139-160.

COLLABORATIVE PAPERS

Uslu, U., Sun, L., Castelli, S., Finck, A.V., Assenmacher, C.A., Young, R.M., Chen, Z.J., June, C.H. (2024). The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion. Nature Communications. 15(1):3933. doi: 10.1038/s41467-024-47692-9.

Chen, H., Chen, H., Zhang, J., Wang, Y., Simoneau, A., Yang, H., Levine, A.S., Zou, L., Chen, Z., and Lan, L. (2020). cGAS suppresses genomic instability as a decelerator of replication forks. Science Advances 6, eabb8941.

Zhang, K., Shang, G., Padavannil, A., Wang, J., Sakthivel, R., Chen, X., Kim, M., Thompson, M.G., García-Sastre, A., Lynch, K.W., et al. (2018). Structural–functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proceedings of the National Academy of Sciences 115, E12218-E12227.

Tian, J., Wu, J., Chen, X., Guo, T., Chen, Z.J., Goldstein, J.L., and Brown, M.S. (2018). BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver. eLife 7, e36826.

Ramachandran, B., Stabley, J.N., Cheng, S.-L., Behrmann, A.S., Gay, A., Li, L., Mead, M., Kozlitina, J., Lemoff, A., Mirzaei, H., et al. (2018). A GTPase-activating protein–binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells. Journal of Biological Chemistry 293, 7942-7968.

Cao, D.J., Schiattarella, G.G., Villalobos, E., Jiang, N., May, H.I., Li, T., Chen, Z.J., Gillette, T.G., and Hill, J.A. (2018). Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury. Circulation 137, 2613-2634.

Moretti, J., Roy, S., Bozec, D., Martinez, J., Chapman, J.R., Ueberheide, B., Lamming, D.W., Chen, Z.J., Horng, T., Yeretssian, G., et al. (2017). STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. Cell 171, 809-823.e813.

Kuss-Duerkop, S.K., Wang, J., Mena, I., White, K., Metreveli, G., Sakthivel, R., Mata, M.A., Muñoz-Moreno, R., Chen, X., Krammer, F., et al. (2017). Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication. PLOS Pathogens 13, e1006635.

Xu, M.M., Pu, Y., Han, D., Shi, Y., Cao, X., Liang, H., Chen, X., Li, X.-D., Deng, L., Chen, Z.J., et al. (2017). Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling. Immunity 47, 363-373.e365.

Choo, M.-K., Sano, Y., Kim, C., Yasuda, K., Li, X.-D., Lin, X., Stenzel-Poore, M., Alexopoulou, L., Ghosh, S., Latz, E., et al. (2017). TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. Journal of Experimental Medicine 214, 1297-1311.

Luo, M., Samandi, L.Z., Wang, Z., Chen, Z.J., and Gao, J. (2017). Synthetic nanovaccines for immunotherapy. Journal of Controlled Release 263, 200-210.

Golden, R.J., Chen, B., Li, T., Braun, J., Manjunath, H., Chen, X., Wu, J., Schmid, V., Chang, T.-C., Kopp, F., et al. (2017). An Argonaute phosphorylation cycle promotes microRNA-mediated silencing. Nature 542, 197-202.

Zhou, W., Xu, J., Li, H., Xu, M., Chen, Z.J., Wei, W., Pan, Z., and Sun, Y. (2017). Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage. Clinical Cancer Research 23, 1104-1116.

Tenekeci, U., Poppe, M., Beuerlein, K., Buro, C., Müller, H., Weiser, H., Kettner-Buhrow, D., Porada, K., Newel, D., Xu, M., et al. (2016). K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping. Molecular Cell 63, 540.

Christensen, M.H., Jensen, S.B., Miettinen, J.J., Luecke, S., Prabakaran, T., Reinert, L.S., Mettenleiter, T., Chen, Z.J., Knipe, D.M., Sandri-Goldin, R.M., et al. (2016). HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. EMBO J 35, 1385-1399.

Kolter, J., Feuerstein, R., Spoeri, E., Gharun, K., Elling, R., Trieu-Cuot, P., Goldmann, T., Waskow, C., Chen, Z.J., Kirschning, C.J., et al. (2016). Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion. J Immunol 196, 2733-2741.

Stein, K., Brand, S., Jenckel, A., Sigmund, A., Chen, Z.J., Kirschning, C.J., Kauth, M., and Heine, H. (2016). Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects. J Allergy Clin Immunol. pii: S0091-6749(16)30609-1. doi: 10.1016/j.jaci.2016.06.018.

Shi, H., Wu, J., Chen, Z.J., and Chen, C. (2015) Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING. Proc Natl Acad Sci U S A 112, 8947-8952.

Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X.D., Wang, J., Choi, J.H., Wang, K.W., Purrington, T., Tang, M, Fina, M, DeBerardinis, RJ, Moresco, EM, Pedersen, G, McInerney, GM, Hedestam, GB, Chen, Z.J, Beutler, B. (2014). MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses. Science 346, 1486-1492.

Rongvaux, A., Jackson, R., Harman, C.C., Li, T., West, A.P., de Zoete, M.R., Wu, Y., Yordy, B., Lakhani, S.A., Kuan, C.Y., Taniguchi, T, Shadel, GS, Chen, Z.J., Iwasaki, A, Flavell, RA. (2014). Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell 159, 1563-1577.

Deng, L., Liang, H., Xu, M., Yang, X., Burnette, B., Arina, A., Li, X.D., Mauceri, H., Beckett, M., Darga, T., Huang, X, Gajewski, TF, Chen, Z.J, Fu, YX, Weichselbaum, RR. (2014). STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors. Immunity 41, 843-852.

Peisley A, Wu B, Xu H, Chen ZJ, Hur S. (2014) Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I. Nature 509, 110-114.

Dai, P., Wang, W., Cao, H., Avogadri, F., Dai, L., Drexler, I., Joyce, J.A., Li, X.D., Chen, Z, Merghoub, T., Shuman S, Deng L. (2014). Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. PLoS Pathog 10, e1003989.

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Yuan, W.C., Lee, Y.R., Lin, S.Y., Chang, L.Y., Tan, Y.P., Hung, C.C., Kuo, J.C., Liu, C.H., Lin, M.Y., Xu, M. Chen, Z.J., Chen, R.H. (2014). K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. Mol Cell 54, 586-600.

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